The Feng lab has developed a next-generation optogenetic system for non-invasive stimulation of neurons
Published in Optogenetics.
Optogenetics has revolutionized neurobiology, allowing researchers to use light to activate or deactivate neurons that are genetically modified to express a light-sensitive channel. This ability to manipulate neuron activity has allowed causal testing of the function of specific neurons, and also has therapeutic potential to reduce symptoms in brain disorders. However, activating neurons deep within a given brain, especially a large primate brain but even a small mouse brain, is challenging, and currently requires implanting fibers that could cause damage or inflammation.